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Received Dec 14; Accepted Dec This article has been cited by other articles in PMC. These CANMAT and ISBD Bipolar Treatment Guidelines represent the significant advances in the field since the last full edition was published inincluding updates to diagnosis and management as well as new research into pharmacological and psychological treatments. In addition to addressing issues in bipolar I disorder, these guidelines also provide an overview of, and recommendations for, clinical management of bipolar II disorder, as well as advice on specific populations, such as women at various stages of the reproductive cycle, children and adolescents, and older adults. There are also discussions on the impact of specific psychiatric and medical comorbidities such as substance use, anxiety, and metabolic disorders. The main objective of these publications was to synthesize the wealth of evidence on the efficacy, safety, and tolerability of the range of interventions available for this complex and varied illness, with the goal of providing clear, easy to use recommendations for clinicians to improve outcomes in their patients. Major conflicting data are addressed in blue text boxes figures to clarify the rationale for arriving at a specific level of evidence for efficacy. In the current edition, an additional distinction is made between safety and tolerability, and a consensus rating is assigned to each medication on these two measures when used in both the acute and maintenance phase. More information on these ratings can be found in the respective treatment sections, as well as in Section 8.

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